Achaogen’s Therapeutic Antibody efforts are focused on developing monoclonal antibodies that are attractive as antibacterial agents

Therapeutic monoclonal antibodies (mAbs) have several distinguishing features that, we believe, make them attractive as antibacterial agents.

  • Antibacterial mAbs are unlikely to be impacted by resistance mechanisms that inactivate existing small molecule-based antibiotics
  • mAbs are highly specific to their target, greatly reducing the potential for toxicity due to off-target binding
  • Humanized or fully human mAbs are likely to be well tolerated with low immunogenicity in patients
  • mAb therapeutics may achieve sustained exposure with a typical half-life of around three weeks, potentially enabling an antibacterial antibody to prevent or cure an infection following a single intramuscular or intravenous dose

Achaogen’s goal is to generate mAbs that could potentially be deployed to treat infections caused by MDR Acinetobacter baumannii and other gram-negative pathogens. 

Based on our experience developing agents for gram-negative pathogens, we have identified a set of targets and a corresponding screening funnel for each target that we believe to be well suited for therapeutic mAb discovery. If successful, our unique approach has the potential to transform the way gram-negative infections are treated by enabling a safe, single-dose primary cure of infection or long-lasting step-down therapy upon discharge from the hospital.

Learn more about how we discover and develop gram-negative product candidates by relying on novel techniques, deep knowledge and expert capabilities.