Achaogen to Present New Data on ACHN-490 at the 50th Annual ICAAC Meeting

- Presentations Highlight Data from Phase 1 Study with ACHN-490 and In Vitro Activity of ACHN-490 Against Resistant Bacterial Pathogens and in Combination with Existing Antibiotics -

SOUTH SAN FRANCISCO, Calif., September 9, 2010 – Achaogen, a biopharmaceutical company and developing antibiotics to treat life-threatening, multi-drug resistant (MDR), today announced key upcoming data presentations involving its lead antibiotic candidate ACHN-490. The data are being presented at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) taking place in Boston from September 12th through September 15th, 2010.

  •  Monday, September 13th from 11:15 am to 1:15 pm: Poster A1-658/7, entitled “Pharmacokinetics (PK) and Safety of ACHN-490 Injection Administered Intravenously for Five Days in Healthy Human Subjects.”
  •  Tuesday, September 14th from 11:15 am to 1:15 pm: Poster E-1563/226, entitled “Activity of ACHN-490 Against Isolates of Methicillin-resistant Staphylococcus aureus (MRSA) from Patients in U.S. Hospitals.”
  •  Wednesday, September 15th from 9:00 am to 11:00 am: Poster E-2059/74, entitled “Activity of ACHN-490, a Neoglycoside, against E. coli (EC) and K. pneumoniae (KP) isolates from New York City (NYC).”
  •  Wednesday, September 15th from 9:00 am to 11:00 am: Poster E-2048/63, entitled “Activity of ACHN- 490 +/- Cefepime, Doripenem, Imipenem, or Piperacillin/Tazoactam Against 10 P. aeruginosa by Synergy Time-Kill.”

In addition to the poster presentations, on Monday, September 15th from 9:00 am to 9:30 am, George H. Miller, Ph.D., research fellow at Achaogen, will be presenting “Aminoglycosides: Past, Present and Future” as part of the Symposium: “Antibiotic Drug Discovery: How Far Have We Come in 50 Years?” Following the meeting, full versions of the posters will be available on the Achaogen website at www.achaogen.com.

About ACHN-490
Achaogen’s most advanced compound, ACHN-490, has been chemically engineered to retain activity against bacteria resistant to carbapenems, cephalosporins, fluoroquinolones, tetracyclines, and legacy aminoglycosides. The compound has demonstrated bactericidal activity in vitro and efficacy in preclinical studies against systemic infections caused by MDR Gram-negative bacteria (e.g., K. pneumoniae, E. coli, and P. aeruginosa) and MRSA. ACHN-490 Injection is currently being investigated in a randomized, doubleblind, comparator-controlled Phase 2 clinical study for the treatment of complicated urinary tract infection (cUTI), the most commonly treated hospital infections in the U.S., and acute pyelonephritis.

About Achaogen
Achaogen is a biopharmaceutical company focused on the discovery and development of antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is applying its anticipatory science to meet this evolving need, developing drugs today intended to combat tomorrow’s resistant pathogens. Achaogen has established specialized capabilities that have enabled the company to pursue multiple discovery and development programs, and has funded its growth with an innovative blend of private investments and non-dilutive funding from partnerships with the NIH, BARDA, the United States Department of Defense, and others. For more information, please visit the company’s website at www.achaogen.com. 

Contacts:
Ashlea Kosikowski, Pure Communications
(910) 547-7093

Achaogen Awarded Contract Worth up to $64 Million by BARDA for the Development of ACHN-490

- Achaogen has Raised More Than $150 Million in Non-Dilutive Funding -

SOUTH SAN FRANCISCO, Calif., August 30, 2010 – Achaogen, a biopharmaceutical company discovering and developing innovative antibiotics to treat life-threatening, multi-drug resistant (MDR) bacterial infections, today announced the award of a contract with The Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services. The contract covers development, manufacturing, and regulatory activities that would position Achaogen’s lead antibiotic candidate ACHN-490 for the treatment of certain biothreat agents, including Yersinia pestis, which causes bubonic plague, and Francisella tularensis, which causes tularemia. The same activities will also provide significant value to the Company’s overall development program for ACHN-490, which includes other life-threatening indications such as complicated urinary tract infections and hospital-acquired pneumonia.

The contract includes a two-year base period with committed funding of $27 million and subsequent option periods that, if completed, would bring the total value of the award to $64.5 million.

“We are pleased to be the first awardee from BARDA’s broad-spectrum antimicrobial initiative” said J. Kevin Judice, Ph.D., chief executive officer and chief scientific officer of Achaogen. “BARDA serves a critical leadership role in the global effort to combat bacterial biothreats and multi-drug resistance at a time when commercial investment is insufficient to meet the challenges we are facing. We look forward to working with BARDA and contributing to global efforts to combat bacterial biothreats and bacterial resistance as we continue the development of ACHN-490.”

With this award, Achaogen has secured significant, non-dilutive funding for all of its ongoing drug discovery and development programs. In aggregate, upon successful completion of its existing government contracts, Achaogen will have received more than $150 million in nondilutive funding.

About ACHN-490
ACHN-490, Achaogen’s most advanced compound, combines excellent solubility, stability, and physicochemical properties with an in vitro spectrum of activity that includes current and emerging multi-drug resistant (MDR) pathogens. ACHN-490 has been chemically engineered to retain activity against bacteria resistant to carbapenems, cephalosporins, fluoroquinolones, tetracyclines, and legacy aminoglycosides. It has demonstrated potent bactericidal activity in vitro and efficacy in preclinical animal models against infections caused by MDR Gram-negative bacteria (e.g., K. pneumoniae, E. coli, and P. aeruginosa) and MRSA. ACHN-490 Injection is being investigated in a randomized, double-blind, comparator-controlled Phase 2 clinical study for the treatment of complicated urinary tract infection (cUTI), the most commonly treated hospital infections in the U.S., and acute pyelonephritis. Subsequent clinical studies are being considered to evaluate ACHN-490 Injection in additional indications, including hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), complicated intra-abdominal infections (cIAI) and blood stream infections (BSI).

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is applying its anticipatory science to meet this evolving need, developing drugs today that will combat tomorrow’s resistant pathogens. Through the use of non-dilutive funding from partnerships with the NIH, the Department of Defense, and BARDA to augment funding from venture investors, Achaogen has established specialized capabilities that have enabled the company to pursue multiple discovery and development programs.

Contacts:
Ashlea Kosikowski, Pure Communications
(910) 547-7093

Achaogen Completes $56 Million Series C Financing

- Proceeds Will Continue to Advance Clinical Development of Novel Antibiotics to Combat Multi-Drug Resistant Gram-Negative Bacteria and MRSA -

SAN FRANCISCO, Calif., April 7 , 2010 – Achaogen, a biopharmaceutical company focused on the discovery and development of innovative broad-spectrum antibiotics to treat life-threatening, multi-drug resistant (MDR) bacterial infections, today announced the completion of a $56 million Series C round of financing. The round was led by new investor Frazier Healthcare Ventures, and also included new investor Alta Partners. Current investors 5 AM Ventures, ARCH Venture Partners, Domain Associates, Venrock Associates, Versant Ventures and the Wellcome Trust also participated in the round. In conjunction with this financing, Robert More, general partner, Frazier Healthcare Ventures, will join the Achaogen board of directors.

“We appreciate the strong support of our existing investors and are pleased to welcome Frazier Healthcare Ventures and Alta Partners to the Achaogen team,” stated Kevin Judice, Ph.D., chief executive officer and chief scientific officer of Achaogen. “Our mission is to discover and develop life-saving antibiotics. This financing together with non-dilutive capital that we have secured through partnerships with various government agencies will enable us to advance multiple clinical programs, including conducting a Phase 2 study in complicated urinary tract infections of ACHN-490, our lead candidate for multi-drug resistant bacterial infections.”

“Frazier Healthcare is excited to work with Alta Partners and Achaogen’s existing investors to support the company’s growth,” said Robert More, general partner, Frazier Healthcare. “Achaogen combines excellent science with a compelling business model, blending venture capital and non-dilutive financing to advance multiple programs that have potential to address the increasing dire need for new agents to treat multi-drug resistant bacteria worldwide.”

Mr. More is a member of Frazier Healthcare’s biopharma and medical device investment teams. Prior to Frazier Healthcare, Mr. More was a partner with Domain Associates. He has also served as the chief operating officer of Small Molecule Therapeutics. Mr. More has served on the boards of ESP Pharma (acquired by Protein Design Labs, Inc.), Proxima Therapeutics (acquired by Cytyc Corporation), Onux Medical (acquired by C.R. Bard), NovaCardia (acquired by Merck), Esprit Pharma (acquired by Allergan) and IntraLase (acquired by Advanced Medical Optics, Inc.).

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is applying its anticipatory science to meet this evolving need, developing drugs today that will combat tomorrow’s resistant pathogens. Through the use of non-dilutive funding from partnerships with the NIH and Department of Defense to augment funding from venture investors, Achaogen has established specialized capabilities that have enabled the company to pursue multiple discovery and development programs. The company’s most advanced drug candidate, ACHN-490, has demonstrated a positive safety and dosing profile in Phase 1 clinical testing and displayed broad spectrum efficacy in preclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. In addition, the company is pursuing preclinical programs in several other areas of interest to combat the global emergence of bacterial resistance.

For more information, please visit the company’s website at www.achaogen.com.

Contact:
Ashlea Kosikowski, Pure Communications
(910) 547-7093