ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates

Andrea Endimiani, Kristine M. Hujer, Andrea M. Hujer, Eliana S. Armstrong, Yuvraj Choudhary, James B. Aggen, and Robert A. Bonomo
Antimicrobial Agents and Chemotherapy, October 2009, p. 4504-4507, Vol. 53, No. 10

Access this publication @ aac.asm.org

Achaogen Announces ACHN-490 Clinical Data at the 49th Annual ICAAC Meeting

- Achaogen’s Neoglycoside Shown to be Well-Tolerated in Phase 1, Dose-Ranging Clinical Trial -

- Additional Preclinical Data Validates ACHN-490’s Consistent Activity Against Gram-Negative and Aminoglycoside-Resistant Bacteria -

SAN FRANCISCO, CA, September 14, 2009 – Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative, broad-spectrum antibiotics, today announced the results of a Phase 1 trial and preclinical data on its lead drug candidate ACHN-490 at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Annual Meeting in San Francisco, CA. ACHN-490 has shown preclinical activity against multi-drug resistant (MDR) Gram-negative and Gram-positive pathogens, and is the most advanced drug in Achaogen’s next-generation aminoglycosides, or neoglycosides.

“We are very pleased with the safety data observed in this Phase 1 clinical trial of ACHN-490,” said Kevin Judice, Ph.D., chief executive officer and chief scientific officer of Achaogen. “The clinical safety data combined with the powerful preclinical efficacy data reinforces ACHN-490’s potential as a novel treatment for multi-drug resistant bacterial infections. We will continue to explore the clinical utility of ACHN-490 in Phase 2 trials, expected to commence in early 2010.”

The Phase 1 trial explored the safety, tolerability and pharmacokinetics (PK) of ACHN-490 in escalating single dose (SD) and once-daily multiple doses (MD) at five different dose levels in a randomized, double blind, placebo-controlled design. Thirty-two subjects were evaluated in four arms of eight subjects per arm (6 active, 2 placebo). There was no evidence of any treatment-related effects on renal, cochlear or vestibular function. Results support the further study of ACHN-490 in high-dose, once-daily, short course therapy in patients with serious infections.

Achaogen also presented additional preclinical data of ACHN-490 in eight posters at ICAAC. Key findings included:

  • ACHN-490 is metabolically stable and its PK profile supports use of high doses in short infusions, administered once-daily to achieve high Cmax and AUC, which are important for safety and efficacy.
  • ACHN-490 demonstrated a potent, rapid, bactericidal effect for strains harboring known resistance mechanisms to widely-used aminoglycosides.
  • ACHN-490 demonstrated consistent activity against leading Gram-negative pathogens, including those with increasingly prevalent resistance mechanisms to other classes of antimicrobial agents.
  • ACHN-490 showed promise as a novel agent against Enterobacteriaceae, including multi-drug resistant KPC+ strains.
  • ACHN-490 is active against pathogens that are the leading causes of complicated urinary tract infections (cUTI), even in the presence of mechanisms causing resistance to current front-line antimicrobial agents.

The ACHN-490 Phase 1 and preclinical data abstracts and posters presented at ICAAC are available online through Achaogen’s website at www.achaogen.com.

“The exciting thing about the preclinical and clinical data on ACHN-490 presented at ICAAC is the translatability of the preclinical efficacy data into humans, combined with the positive safety profile observed in healthy volunteers,” stated Joseph S. Solomkin, M.D., professor of surgery at the University of Cincinnati. “With antibiotic drug development, the results we see in animal models tend to be more predictive of human experience because the microbials or bugs are the same – only the host is different. With that in mind, these data are very promising for ACHN-490 as an emerging weapon in the fight against multi-drug resistant bacteria.”

About ACHN-490
Achaogen’s novel aminoglycoside agents—neoglycosides—overcome known aminoglycoside resistance mechanisms as well as resistance mechanisms that thwart other well-known classes of antibiotics. Leveraging modern chemistry and biology, as well as the extensive scientific and clinical knowledge gained from decades of aminoglycoside usage, Achaogen is poised to enhance the prominence and utility of this important class of antibacterials against 21st-century pathogens.

Achaogen’s lead neoglycoside, ACHN-490, has displayed efficacy in research and nonclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. Achaogen recently completed a Phase 1 randomized, double blind, placebo-controlled trial assessing the safety, tolerability and pharmacokinetics in escalating single (SD) and once-daily multiple (MD) doses up to five doses of ACHN-490. Achaogen plans to initiate a Phase 2 clinical trial of ACHN-490 in patients with complicated urinary tract infections (cUTI) in early 2010.

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of innovative, broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is poised to meet the evolving needs of this market by applying its anticipatory science, developing drugs today that will combat tomorrow’s resistant pathogens. This scientific strategy represents a novel approach to addressing the global bacterial resistance crisis.

South San Francisco-based Achaogen is backed by top-tier venture investors and has received substantial non-dilutive funding from NIH, the U.S. Department of Defense, the Wellcome Trust and other sources. Venture capital investors include 5 AM Ventures, ARCH Venture Partners and Domain Associates, Venrock Associates and Versant Ventures. For more information, please visit the company’s website at www.achaogen.com.

Contacts:
Dan Budwick, Pure Communications
(973) 271-6085

Ashlea Kosikowski, Pure Communications
(910) 547-7093

Synthesis, Structure, and in vitro Activity of the Neoglycoside ACHN-490

James B. Aggen, Eliana S. Armstrong, Adam A. Goldblum, Paola Dozzo, Martin S. Linsell, Micah J. Gliedt, Darin J. Hildebrandt, Lee Ann Feeney,Aya Kubo, Rowena D. Matias, Sara Lopez, Marcela Gomez, Kenneth B. Wlasichuk, Raymond Diokno, George H. Miller, Heinz E. Moser
Achaogen, Inc.
ICAAC 2009, poster # F1-840

Download poster as PDF 

The Bactericidal Activity of the Neoglycoside ACHN-490 Against Aminoglycoside-Resistant Bacteria

Gary Zurenko, Douglas Stapert, Mary Knechtel, Nanette Nichols, Dean Shinabarger, Eliana S. Armstrong, James B. Aggen, Lee Ann Feeney, Aya Kubo, Rowena D. Matias, George H. Miller
Micromyx, Achaogen Inc.
ICAAC 2009, poster # F1-841

Download poster as PDF 

Achaogen Appoints John C. Doyle to the Newly Created Position of Chief Operating Officer

San Francisco, CA, August 25, 2009 – Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative, broad-spectrum antibiotics, announced today the appointment of John C. Doyle to the newly created position of chief operating officer. Mr. Doyle brings years of experience in leadership roles managing business and financial operations, strategic and operational planning, equity financing, strategic alliances and R&D program management with biotechnology companies including Genentech, Renovis and Tularik.

“As we continue to expand and develop our pipeline and prepare to enter Phase 2 development with our lead product candidate ACHN-490, we are planning for the future growth of Achaogen,” said Kevin Judice, Ph.D., chief executive officer and chief scientific officer of Achaogen. “John’s experience in both large and emerging biotech companies, as well as his diverse background in public and private financings, corporate development and operations, will be important to Achaogen as we continue to execute on our business strategy.”

Mr. Doyle joins Achaogen from Genentech, a leading biotech company acquired by Roche in March 2009, where he served as vice president of finance and corporate planning. Previously, he served as chief financial officer and senior vice president of corporate development at Renovis (acquired by Evotec AG), a publicly-held biotech company focused on neurological diseases and disorders. Mr. Doyle has also held positions at Tularik (acquired by Amgen) and PricewaterhouseCoopers. Mr. Doyle received an M.B.A. from the Haas School of Business at the University of California, Berkeley, and a B.S. from Cal Poly, San Luis Obispo.

“There is a clear and growing need for new antibiotics as multi-drug resistant bacterial infections become more prevalent worldwide,” commented Mr. Doyle. “The Achaogen team is deeply committed to addressing this serious and growing threat to public health and I am excited to join the effort.”

About ACHN-490
Achaogen’s novel aminoglycoside agents—neoglycosides—overcome known aminoglycoside resistance mechanisms as well as resistance mechanisms that thwart other well-known classes of antibiotics. Leveraging modern chemistry and biology, as well as the extensive scientific and clinical knowledge gained from decades of aminoglycoside usage, Achaogen is poised to enhance the prominence and utility of this important class of antibacterials against 21st-century pathogens.

Achaogen’s lead neoglycoside, ACHN-490, has displayed efficacy in research and nonclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. The company initiated a Phase 1 clinical study in early 2009 and data from this study are expected in the second half of 2009.

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of innovative, broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is poised to meet the evolving needs of this market by applying its anticipatory science, developing drugs today that will combat tomorrow’s resistant pathogens. This scientific strategy represents a novel approach to addressing the global bacterial resistance crisis.

South San Francisco-based Achaogen is backed by top-tier venture investors and has received substantial non-dilutive funding from NIH, the U.S. Department of Defense, the Wellcome Trust and other sources. Venture capital investors include 5 AM Ventures, ARCH Venture Partners and Domain Associates, Venrock Associates and Versant Ventures. For more information, please visit the company’s website at www.achaogen.com.

Contacts:
Ashlea Kosikowski, Pure Communications
(910) 547-7093

FierceBiotech Names Achaogen as One of the “Fierce 15" Biotech Companies of 2009

- Achaogen is on Leading Edge of Biotech -

San Francisco, CA, June 30, 2009 – Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative broad-spectrum antibiotics, announced today that it has been selected as one of the annual FierceBiotech “Fierce 15” list, designating it as one of the top biotech companies of 2009. The editors of FierceBiotech evaluated hundreds of privately-held firms based on vision, revenue potential, quality of deals, strength of technology, partnerships, and competitive market position.

An internationally recognized daily newsletter reaching more than 65,000 biotech and pharma industry professionals, FierceBiotech provides subscribers with a quick authoritative briefing on the day’s top stories, with a special focus on drug discovery and clinical trials.

“New insights have helped Achaogen create a new and differentiated antibiotic – and that’s important in a field that is dominated by therapies fated to become obsolescent. An innovative blend of venture capital and non-dilutive financing sources has helped bankroll this five-year-old biotech, which is firmly focused on improved efficacy with fewer side effects. Achaogen has good science and a sound business model, which is rarely paired in any industry,” said John Carroll, Editor of FierceBiotech.

"FierceBiotech is highly valued for its advanced understanding of biotechnology companies and the industry as a whole," said Kevin Judice, Ph.D., Chief Executive Officer and Chief Scientific Officer of Achaogen. "Being selected as a member of the ‘Fierce 15’ is an honor that recognizes Achaogen’s potential to make a significant impact in the biotech and antibacterial market.”

The Fierce 15 celebrates the spirit of being “fierce” – championing innovation and creativity, even in the face of intense competition. The complete list of ‘Fierce 15’ companies is available in today’s issue of FierceBiotech and on the FierceBiotech Web site at www.fiercebiotech.com.

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of innovative, broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is poised to meet the evolving needs of this market by applying its anticipatory science, developing drugs today that will combat tomorrow’s resistant pathogens. This scientific strategy represents a novel approach to addressing the global bacterial resistance crisis.

South San Francisco-based Achaogen is backed by top-tier venture investors and has received substantial non-dilutive funding from NIH, the U.S. Department of Defense, the Wellcome Trust and other sources. Venture capital investors include 5AM Ventures, ARCH Venture Partners and Domain Associates, Venrock Associates and Versant Ventures. For more information, please visit the company’s website at www.achaogen.com.

About FierceMarkets
FierceMarkets is a digital business media serving vertical markets with email newsletters, web sites, and live events. Based in Washington, DC, FierceMarkets publications reach more than 450,000 executives in over 100 countries every business day. Current publications include The Business VoIP Report (http://www.businessvoipreport.com), FierceBioResearcher (http://www.fiercebioresearcher.com), FierceBiotech (http://www.fiercebiotech.com), FierceBroadbandWireless (http://www.fiercebroadbandwireless.com), FierceCIO (http://www.fiercecio.com), Fierce CIO: Tech Watch (http://www.fiercecio.com/techwatch), FierceDeveloper (http://www.fiercedeveloper.com), FierceFinance (http://www.fiercefinance.com), FierceFinanceIT (http://www.fiercefinanceit.com), FierceHealthCare (http://www.fiercehealthcare.com), FierceHealthFinance (http://www.fiercehealthfinance.com), FierceHealthIT (http://www.fiercehealthit.com), FierceIPTV (http://www.fierceiptv.com), FierceMobileContent (http://www.fiercemobilecontent.com), FierceMobileIT (http://www.fiercemovbileit.com), FierceOnlineVideo (http://www.fierceonlinevideo.com), FiercePharma (http://www.fiercepharma.com), FierceSarbox (http://www.fiercesarbox.com), FierceTelecom (http://www.fiercetelecom.com), FierceVaccines (http://www.fiercevaccines.com), FierceVoIP (http://www.fiercevoip.com), FierceWireless (http://www.fiercewireless.com), and FierceWireless: Europe (http://www.fiercewireless.com/europe).

Contacts:
Ashlea Kosikowski, Pure Communications
(910) 547-7093

Heather Cox, FierceMarkets, Inc.
(202) 628-8778 x13

Achaogen Data Show Rapid Rise in Rates of Resistance to Current Antibiotics; Illustrate Global Need for New, Well-Tolerated Agents to Address Varied Mechanisms of Resistance

- Data Presented at European Congress of Clinical Microbiology and Infectious Diseases -

SAN FRANCISCO, UNITED STATES and HELSINKI, FINLAND, May 16, 2009 – Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative broad-spectrum antibiotics, announced today the presentation of research on aminoglycoside (AG) resistance trends and comparative AG toxicities at the 19th Annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), being held May 16-19, 2009 in Helsinki, Finland.

In three separate sessions, Achaogen and its research collaborators, including the Jones Microbiology Institute Laboratories in Iowa and Paul M. Tulkens, M.D. of the Université catholique de Louvaine, Belgium, are highlighting study results that underscore the critical need for well-tolerated, next-generation AGs to combat multi-drug resistant Gram-negative pathogens and address a growing public health concern. AGs have been part of the clinical infectious disease armamentarium for roughly half a century; however, as the Achaogen and JMI Laboratories research shows, rates of bacterial resistance to existing AGs, including such widely used agents as gentamicin and amikacin, are far higher in all parts of the world than was expected, suggesting a need for a next-generation AGs that can treat these resistant pathogens.

“The data being presented at ECCMID demonstrate that global resistance to AGs is increasing more rapidly than previously thought, and shows that resistance mechanisms of various Gram-negative pathogens are limiting the utility of other currently marketed antibiotics across most, and possibly all known drug classes,” stated Kevin Judice, Ph.D., chief executive officer and chief scientific officer of Achaogen. “Bacteria are constantly evolving and becoming more resistant, and these findings reinforce the urgent need for new therapies to combat these varied mechanisms of resistance.”

Achaogen’s novel aminoglycoside agents—neoglycosides—have shown broad-spectrum efficacy in vitro and in vivo against a wide range of multi-drug resistant Gram-negative organisms (including E. coli, K. Pneumoniae, P. aeruginosa, and Enterobacter spp.), as well as multi-drug resistant Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus (VRSA). They also overcome known aminoglycoside resistance mechanisms. Achaogen’s most advanced neoglycoside, ACHN-490, is being studied in a Phase 1 trial and initial clinical data are expected later this year.

Overview of Findings
“Ten-year trend in aminoglycoside resistance from a worldwide collection of Gram-negative pathogens” (Saturday, May 16); Poster # 636
The study assessed resistance trends to aminoglycosides over a ten-year period, using a global sample of Gram-negative pathogens. This study determined the resistance rates of commonly prescribed AGs (gentamicin, tobramycin, amikacin) against over 20,000 bacterial strains from nine Gram-negative bacterial species gathered from medical centers around the world. In particular, resistance to AGs from E. coli, the most common Gram-negative pathogen isolated in the study, increased in all geographic regions. Notably, in regions outside of North America, more than 50% of Acinetobacter spp. and more than 20% of P. aeruginosa isolates collected during 1998-2007 were resistant to gentamicin. The highest rates of AG resistance were observed in the Latin America and Asia-Pacific regions. The study results underscore the global issue of bacterial resistance to available AGs, and the value of developing new therapies, such as Achaogen’s neoglycosides, to treat multi-drug resistant Gram-negative infections.

“Surveying aminoglycoside resistance mechanisms: a tool for the development of neoglycosides” (Saturday, May 16); Poster #643
Surveying AG resistance mechanisms among selected clinical isolates allows researchers to determine the spectrum of activity required of new compounds to overcome bacterial resistance to existing agents. In this study, multi-drug resistance was defined by resistance to three drug classes: aminoglycosides, fluoroquinolones and cephalosporins. The results demonstrate that while the overall prevalence of resistance to AGs is increasing, the distribution of AG-resistant mechanisms amongst AG-resistant isolates worldwide has remained stable during the past 20 years, suggesting that new agents that evade these mechanisms, such as neoglycosides, should remain useful for a long period of time against today’s AG-resistant bacteria.

In addition, a poster entitled “Quantitative comparison of aminoglycosides nephrotoxicity in rats for effective screening and evaluation of new derivatives, and dosing rationales that minimize toxicity,” Poster #1979, will be presented on Tuesday, May 19 at the ECCMID. This poster reviews data from a newly refined rat toxicity model that effectively quantifies the comparative nephrotoxicity of various aminoglycosides. This model allows for effective preclinical screening of Achaogen’s neoglycosides, and has informed the company’s selection of optimal dosing for clinical studies.

About ACHN-490
Achaogen’s novel aminoglycoside agents—neoglycosides—overcome known aminoglycoside resistance mechanisms. Leveraging modern chemistry and biology, as well as the extensive scientific and clinical knowledge gained from decades of aminoglycoside usage, Achaogen is poised to enhance the prominence and utility of this important class of antibacterials against 21st-century pathogens.

Achaogen’s lead neoglycoside, ACHN-490, has displayed efficacy in research and nonclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. The company initiated a Phase 1 clinical trial in early 2009 and data from this trial are expected in the second half of 2009.

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of innovative, broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is poised to meet the evolving needs of this market by applying its anticipatory science, developing drugs today that will combat tomorrow’s resistant pathogens. This scientific strategy represents a novel approach to addressing the global bacterial resistance crisis.

South San Francisco-based Achaogen is backed by top-tier venture investors and has received substantial non-dilutive funding from NIH, the U.S. Department of Defense, the Wellcome Trust and other sources. Venture capital investors include 5 AM Ventures, ARCH Venture Partners and Domain Associates, Venrock Associates and Versant Ventures. For more information, please visit the company’s website at www.achaogen.com.

Contacts:
Ashlea Kosikowski, Pure Communications
(910) 547-7093

Achaogen Selected to Present at InsideVenture’s Debut Investor Conference

- March 25-26, Santa Barbara, California -

SAN FRANCISCO, CA, March 23, 2009 – Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative broad-spectrum antibiotics, today announced that J. Kevin Judice, Ph.D., chief executive officer and chief scientific officer, will present at InsideVenture’s Debut Conference, March 25-26, 2009 in Santa Barbara, California. Achaogen has been selected from over 170 nominations to be one of 50 top private companies showcased to long-term investors through presentations and 1-on-1 meetings at the invitation only conference. InsideVenture’s Selection Boards includes Founders and Partners of leading venture firms including NEA, Venrock, DCM, Domain, Frazier, Clarus, Oak Investment, Aisling, and Versant. Over 130 investors are represented in the selected companies.

“We are honored to support Achaogen in their private funding efforts through our online platform and at our debut transactional conference in Santa Barbara,” said Mona DeFrawi, chief executive officer of InsideVenture. “InsideVenture was created as a powerful and cost-effective platform to support the companies that grow our economy by facilitating their late stage and pre-IPO financing needs. Structural changes in the capital markets over the past 10 years have blocked the real path to economic growth by challenging the financing of the companies delivering valuable new products, jobs and profits for the world economy. These top 50 companies have invested in innovation, and now InsideVenture is innovating the investment process to support their continued growth.”

“Achaogen is pleased to use InsideVenture’s new financing platform because it provides an efficient means to access and build relationships with a number of high quality private investors,” said Dr. Judice.

InsideVenture Investor Conference – March 25-26, Santa Barbara, California
Achaogen is one of 50 top late-stage private healthcare and technology companies seeking to raise $20-200+M or establish and develop relationships with new investors prior to an eventual IPO. The companies will present their businesses to qualified institutional buyers (QIBs), including mutual fund managers, crossover funds, late stage VC & PE funds and strategic corporate investors. Investors interested in attending the conference may apply for an InsideVenture trial membership; the conference is exclusive to members and by invitation only.  The theme of this year’s conference is “Investing in Innovation: Innovation in Investing”.  Investors should contact InsideVenture today to apply for membership and an invitation to the InsideVenture Investor Conference, March 25-26, 2009 in Santa Barbara, California.

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of innovative, broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is poised to meet the evolving needs of this market by applying its anticipatory science to develop drugs today that will combat tomorrow’s resistant pathogens. This scientific strategy represents a novel approach to addressing the global bacterial resistance crisis. Achaogen is creating new medicines that anticipate the next wave of anti-bacterial infections, including agents for the underserved Gram-negative infectious disease market and methicillinresistant Staphylococcus aureus (MRSA). Achaogen’s most advanced compound, ACHN-490, one of the company’s next generation aminoglycosides known as neoglycosides, entered the clinic in January 2009, and the company has several other innovative small molecule antibacterial programs nearing clinical development. South San Francisco-based Achaogen is backed by top-tier venture investors and has received substantial non-dilutive funding from NIH, the U.S. Department of Defense, the Wellcome Trust and other sources. Venture capital investors include 5 AM Ventures, ARCH Venture Partners and Domain Associates, Venrock Associates and Versant Ventures. For more information, please visit the company’s website at www.achaogen.com.

About InsideVenture
InsideVenture is an industry sponsored financial marketing utility creating a direct private market platform for institutional and strategic investment in late-stage private companies. InsideVenture’s exclusive vetting and membership requirements connect the best late-stage
venture-backed companies with revered long-term institutional and strategic investors to facilitate late-stage transactions, IPO participation and aftermarket support. InsideVenture is supported by investment leaders and partners like T. Rowe Price, Wasatch Advisors, SVB
Financial Group, NYSE, Alexandria Equities, Intralinks Corporation, New Enterprise Associates, Domain Associates, DCM, Venrock Associates, Versant Ventures, Frazier Healthcare Ventures, Clarus Ventures, and Aisling Capital among others. InsideVenture is based in Menlo Park, California and on the web at www.insideventure.com.

InsideVenture Conference & Membership Contact:
Benjamin Levy, Vice President
650-926-0661
blevy@insideventure.com

InsideVenture Media Contact:
Matthew Stotts
TENOR
415.786.2231
matthew@tenorcom.com

Achaogen Contact:
Sondra Newman, Pure Communications
(617) 877-5687

Achaogen to Present at Cowen and Company 29th Annual Health Care Conference

SAN FRANCISCO, CA, March 10, 2009 – Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative broad-spectrum antibiotics, today announced that J. Kevin Judice, Ph.D., chief executive officer and chief scientific officer, is scheduled to present at the Cowen and Company 29th Annual Health Care Conference on Tuesday, March 17, 2009 at 3:00 p.m. EDT at the Boston Marriott Copley Place in Boston, Mass.

About Achaogen
Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of innovative, broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. Resistance to available antibacterial therapies continues to rise at an alarming rate, and Achaogen is poised to meet the evolving needs of this market by applying its anticipatory science to develop drugs today that will combat tomorrow’s resistant pathogens. This scientific strategy represents a novel approach to addressing the global bacterial resistance crisis. Achaogen is creating new medicines that anticipate the next wave of anti-bacterial infections, including agents for the underserved Gram-negative infectious disease market and methicillin-resistant Staphylococcus aureus (MRSA). Achaogen’s most advanced compound, ACHN-490, one of the company’s next generation aminoglycosides known as neoglycosides, entered the clinic in January 2009, and the company has several other innovative small molecule antibacterial programs nearing clinical development. South San Francisco-based Achaogen is backed by top-tier venture investors and has received substantial non-dilutive funding from NIH, the U.S. Department of Defense, the Wellcome Trust and other sources. Venture capital investors include 5 AM Ventures, ARCH Venture Partners and Domain Associates, Venrock Associates and Versant Ventures. For more information, please visit the company’s website at www.achaogen.com.

Contacts:
Sondra Newman, Pure Communications
(617) 877-5687